This is the 5th of 5 series:
Part 1: Don’t Take Resistant Starch Alone and Other Precautions; RS2 Needs to Be Taken With Other Fiber To Spread Fermentation Completely Across the Entire Colon
Part 2: Real Food Resistant Starch (RS3) Trumps High-Dose Potato Starch Diet To Expand the Lean and Immunoprotective Core Microbiota (Roseburia, Eubacteria, F. prausnitzii, Bifidobacteria)
Part 3: Don’t Take Resistant Starch If You Have Moderate to Severe Irritable Bowel Syndrome (IBS) Temporarily
Part 4: Don’t Eat Raw Resistant Starch (RS2) If Pre-Cancerous or Cancerous for Colorectal Cancer, Temporarily
Part 5: Don’t Take Raw Potato Starch (RPS) Temporarily If You Have an Autoimmune Disorder
Autoimmune disorders: if RS eaters are in the small intestines or severe intestinal permeability continues to allow normal gut microbes to leach into the blood, don’t take any resistant starch and digestible starches temporarily.
How do you know? Cooked starches or raw RS make you very sick, flu-like, muscle achy, headachey, constipated, diarrhea, or bloated.
Fix your gut by seeding, weeding, then feeding the missing populations of gut guardians like soil probiotics, Bifidobacteria, Roseburia and Akkermansia.
Various autoimmune disorders implicate microbes that selectively prefer digestible starch and resistant starch. Through of a process known as molecular mimicry the body mistakenly attacks its own tissues (joints, brain, bowels) in an ancient programmed attempt to contain the invading enteric microbe leaching into the blood and lymph circulation (Ebringer et al, 2011 and 2013):
–spirochete Borrelia burgdorferi
—Morganella morganii (I had this one, REALLY FUN, had to SEED/WEED)
I had to seed-weed out a few things before I fixed my gut (my n=1). Just recently I retested and I’ve maintained a parasite free gut after weeding and by using bionic fiber version B (7-Steps) and soil probiotics.
Which inflammatory and autoimmune disorders are characterized by the above microbial fingerprints?
Rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, psoriasis, inflammatory bowel disease (Crohn’s, ulcerative colitis), celiac disease, Grave’s and Hashimoto’s thyroiditis, allergy and asthma, etc.
SEEDING-WEEDING: TENDING YOUR INNER HORTICULTURE
Seeding with great probiotics helps crowd out weeds without toxicity or carpet bombing: Step #3 Probiotics — soil based, bifidobacteria, lactobacilli. This includes all of our beneficial symbionts that antibiotics and high sugar diets kill off.
Ashwin Patel finds neem (Himalaya HH, TheraNeem) to be great for many gut applications: antifungal, weeding, antiparasitic/microbial, help the flow of bile, liver and skin. Tim Steele loves botanical/medicinal mushroom teas; these are potent weeders and anti-inflammatory. He’s used it for many years. To blunt die-off, don’t forgot charcoal, bentonite and edible earth.
After antibiotics the above adverse microbes can flourish if already present or newly introduced. Antibiotics have multiple ways of silently damaging our bodies. Antibiotics are so potent. By wiping out ‘bad’ flora, the collateral damage is annihilation and genocide of the ‘good’ microbes that are the sentinels of the gut. I like botanical ways of ‘weeding’ instead because these are often gentler (not always) and can preserve the gut guards like Bifidobacteria, Roseburia and Akkermansia better. The damage left by antibiotics allows the below to proliferate:
—Candida, Aspergillus, etc yeasts
–parasites (eg, E nana, I also had; B hominii, way more common than you’d think)
–protozoa (giardia, malaria, etc)
–viruses (herpes, EBV, CMV, etc)
On the contrary, cell counts (CFU/ml) of presumptive Bacteroides, Staphylococcus, Salmonella, Shighella and Klebsiella were significantly higher (P = 0.014) in T-CD [TREATED CELIAC DISEASE] compared to HC children [NON-CELIAC HEALTHY CONTROLS]. —DiCagno et al 2011
Candida proteins resemble gluten — once an immune reaction against candida occurs, then ginormous gluten intolerances develop. Celiac can be one if the right HLA DQ2/8 immune cells are around. The body attacks food-based wheat, barley, rye and oats with a vengeance because these contain (or are cross contaminated) with gluten. Stopping gluten allows the immune system/gut to calm down. This is Step #6 of the 7 Steps and one of the most critical.
Klebsiella pneumonia proteins resemble the collagen in joints, skin and connective tissues all over the body. If the gut is leaky and K. pneumonia breaches into the blood circulation and triggers immunity, then several inflammatory or autoimmune conditions may form. AS is an autoimmune reaction where the body attacks joints in the spine and all over the body. Klebsiella is implicated in nearly autoimmune disease including celiac disease because it is such a strong gut disruptor and opportunistic viper. The heritability and genetics of RA, celiac and other autoimmune disorders has not changed. What has changed are the mass extinctions occurring in our inner gardens. Celiacs are not born, they are created by antibiotics and the deficiency of the guardians of the gut.
The prevalence of HLA-B27 varies markedly in the general population. For example, about 8% of Caucasians, 4% of North Africans, 2-9% of Chinese, and 0.1-0.5% of persons of Japanese descent possess this gene. In northern Scandinavia (Lapland), 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis. –Wikipedia
HLA B27, New Autoimmune Disease Affecting Millions (Ebringer et al, 2007)
Ann N Y Acad Sci. 2007 Sep;1110:112-20.
B27 disease is a new autoimmune disease that affects millions of people.
“B27 disease” is a new autoimmune disease that afflicts millions of people throughout the world. “B27 disease” occurs in individuals who have ankylosing spondylitis (AS) or preankylosing spondylitis and/or uveitis and are also positive for HLA-B27. Molecular mimicry between the bowel microbe Klebsiella and the HLA-B27 molecule, as well as the spinal collagens types I, III, and IV, indicates a pathological mechanism involving autoimmunity. Antibodies to Klebsiella microbes have been reported in AS patients from 18 different countries. Sera from patients with AS show complement-dependent cytopathic activity against sheep red cells coated with HLA-B27 peptide antigens. Diagnosis of B27 disease can lead to early treatment, involving low-starch diet, sulfasalazine, and immunosuppressive and biological agents so as to prevent the irreversible bony changes of established classical AS. The concept of B27 disease provides a new approach to the study and treatment of these disorders and needs to be evaluated in prospective studies by the world rheumatological community.
FEEDING: RAW POTATO STARCH MAY WORSEN SOME AUTOIMMUNITY AND INFLAMMATORY CONDITIONS
Some autoimmunity will not respond well to raw potato starch or raw green banana flour. It depends if SIBO/SIFO is present — microorganisms growing inappropriately in the small intestines — and which organisms are growing there. If any of the listed bugs from above consume RS2, then there might be problems and worsening of autoimmunity.
IMHO Most individuals just are not that ‘in tune’ with their bods to identify if something is truly jiving in the gut or not. Please test, don’t guess. B-I-O-H-A-C-K.
Figure out if you are low in one or many of your ancestral symbionts. Inventory an accurate list of what is in your black box, particularly if you have had or have currently an autoimmune disorder. Don’t shift your gut into a shittier situation.
My favorite test is the Genova Diagnostics 2200 Stool which was recently upgraded to include some of my 7 ancestral core species. This progressive stool test will change modern medicine! Microbiome-based diagnostics and therapeutics will wipe out conventional healthcare because it offers routes to identify what’s actually and truly ‘wrong’.
- Klebsiella appears to both consume raw RS2 and digestible starches – this is the big problem for Alkylosing Spondylitis (AS) and HLA B27.
- Prevotella and other Bacteroidetes can consume RS2 and ‘bloom’ with raw RS2 and starches. Prevotella overgrowths are highly implicated in many autoimmune and inflammatory conditions: Rheumatoid Arthritis (RA), new onset RA, reactive arthritis, obesity (6-fold higher), T2 diabetes, smokers, UC/IBD, multiple sclerosis, and psoriasis.
- Metabolic gut cross feeders — I have no idea who these are but in an unhealthy, unbalanced gut, often these are present. If adverse effects occur with raw potato starch or green banana flour, then these are likely to be present. They break down RS2 to make products of starch hydrolysis, that feed one or several of the above listed pathogenic microbes.
CROWDING OUT CANDIDA, KLEBSIELLA AND/OR PREVOTELLA
To crowd out the above opportunistic vipers, try to achieve as perfect as possible digestion, probiotics and inulin to help move them out of the small intestines. A low starch diet initially helps improve Kleb, Candida or Prevotella overgrowths. The 7 steps, removing yeasts and parasites, gastric acidity and the flow of bile are all vital. Inulin (bionic fiber version B) lowers Prevotella where on the other hand raw potato starch may strongly flare it. Raising the beneficial symbionts will further eradicate any remaining vipers — the ancestral soil probiotics, Bifidobacteria/B. longum, Roseburia and Akkermansia. These populations grow and thrive when we make a point to eat a diverse and varied rainbow of cooked-cooled RS3 and avoid high-dose raw maize or potato starch which unfortunately LOWERS ALL OF THEM. Depending on the balance and composition of organisms in the gut, high dose potato starch may worsen these gut profiles if Prevotella or Klebsiella is a dominating gut growth. Just as in high risk or pre-cancerous colorectal cancer, high dose potato starch is likely to contribute to exacerbation of a detrimental and carcinogenic gut microbiota ‘fingerprint’ by promoting low Roseburia and Clostridia clusters XIVa, the main butyrate factories of our guts.