Alanna Featured ImageIt’s become a common phrase throughout those who are involved with the microbiome: we are 10% Human. The other 90% of the genes in our body are from our microbes. Alanna Collen joins the show to discuss just this. Grace and Matt dig in to Alanna’s newest book, “10% Human: How Your Body’s Microbes Hold the Key to Health and Happiness.” Alanna discusses her research in the microbiome and its importance for our everyday lives. This episode explores antibiotics and weight gain, leaky gut, and asking the right questions about microbiome. 

Show Notes



  • darlingjojo

    Loved listening to this podcast. Really like finding out about the other probiotic offerings. I will be trying to get the one from the UK if possible.

  • Ricky

    Hey Dr. Grace!

    Big fan of all of your work. I have a quick question. I believe I struggle with some GI issues autoimmune type issues and acne. I don’t really tolerate starch or RS or FODMAPS. I also don’t tolerate any of the bionic fibers. I am in the process of healing what I believe to be a leaky gut. I really would like to incorporate a fiber so I can build my gut flora up and heal my gut! I’m on a million botanicals and herbs and probiotics/sbo’ for my gut lining but what fiber is safe? I know Inulin and Acacia gum doesn’t work well with me. When I stay away from all the above foods I do get symptom relief, but I don’t feel as though I am actually healing. I have been carpet bombing my gut with antimicrobials and even a few rounds of rifaximin so I know pretty much my gut flora is non existent!

    Which fiber is safe? Would glucomannan be a good choice? If so how much? If not any other fibers? Thank you so much for your help

    • DrGracePharmD-Gut_Goddess

      HI Ricky

      Great question. Any of the non-FODMAP fibers and prebiotics are awesome. See what you tolerate and see what are the suspected potential pathogens (typically they feed on sugar and starch/raw starches) like E coli, clostridium and yeasts.

      Consider: glucomannan, pectin/MCP, arabinogalactan, psyllium, etc

      I’d avoid anything with beta-glucan because it resembles the cell walls of yeasts/candida and frequently will cross-react.

      At some point you want to re-gain the ability to digest FODMAPs again as these feed all the beneficial symbionts which will keep the pathogens to minimal levels (E coli, clostridium, yeasts, parasites, etc). Probiotics and a healed gut do this! Which probiotics are working for you?

      • Ricky

        Thank you so much for the response!

        Right now I take Prescript Assist, UltimateFlora BifidoMax and S boulardi

        Doyou think by taking those specific non-starch non FODMAP fibers along
        with the probiotics I’ll heal my gut enough to actually be able to enjoy
        starch and Fodmaps and restore my gut flora/ leaky gut and resolve my
        autoimmune issues so I can live my life again! 😛

        think I will try pectin, glucomannan and MCP. I’m nervous about
        arabinogalactan because it is a monosaccharide and psyllium may trigger

        Do you have a recommendation on how much of those fibers daily?

        Hopefully those probiotics and fiber sources will be enough to seed and weed my gut of any potential pathogens!

        Thank you so much for you help! You need to have a donate button for
        all the amazing help and work you do! You truly are making the world a
        healthy and better place 🙂

  • Samantha Rodes

    Hello, Grace! I know it’s been a while, but a little update and questions-
    My constipation is back. GRRRRR. I’ve dug into more research, and found that high (not balanced?) levels of clostridia and Staphylococci are associated with constipation.
    I’ve tried antimicrobials for a month, felt awful. Cut out all probiotics fermented foods.
    Couldn’t take it anymore, and went back to what I cut out.
    Motility/Regularity improved for about a week and a half, and then-
    Constipation returned with a vengence. When I lie on my back and massage my belly, I can feel the food trapped inside.
    My current probiotic protocol-
    1 Prescript Assist before bed w/ acacia fiber, Eco Bloom (body ecology- FOS), magnesium citrate (CALM), 1 cap of Organic India Triphala, and D-Limonene.
    I get pellets with this alone. HOWEVER, I get NOTHING when I take AOR-Probiotic 3. NOTHING.
    I’m cutting out AOR. It’s causing cramps. If I take it out, the cramps go away.
    But I wake up like clockwork at 6:20 feeling tired, full, and depressed. My skin is good, though.
    Would like your thoughts on any ways to reduce clostridia/staph. Or if there’s anything more that can be done. I’m SICK of this roller coaster.

    • DrGracePharmD-Gut_Goddess

      Samantha, IBS-C is tough for some. I love using MCT oil and glucomannan and arabinogalactan.

      Clostridia/staph go away with re-installation of our ancestral core and working on all aspects of digestions
      –parasympathetic nervous system (vagal)
      –bacteria of the ancestral core
      –removing pathogenic fungi/bacteria

      I think you are on a great path

  • Jason

    Hi Grace. Thanks for the podcasts and posts. Your work (and broadcasting of other people’s gut work) is so important and fascinating. What was the name of the product mentioned in this podcast that is being used to mop up LPS in obese people with leaky gut? Is that available? I am using a product called enteragam that has the same action, and I have seen some benefit from it. Question of the day: why do you recommend probiotics and even fermented foods for SIBO while many SIBO practitioners advise against them, especially during the weeding phase. I am staring a biocidin killing protocol and can’t decide whether to keep taking probiotics or wait. Right now, I have VSL#3 and Florastor in my arsenal.

    • DrGracePharmD-Gut_Goddess


      Matt and I appreciate your kind words!

      Mmhh was it bentonite clay and charcoal? These bind microbial toxins as well as drugs/meds.

      Are you taking enteragam for IBS diarrhea or constipation or mixed? Is your insurance covering and what is cost for you?

      There are various types of SIBO. Some are FODMAP intolerant and some are starch intolerant, then many are in between like histamine intolerance. Fermented foods are a problem for those with high reactions against histamine and/or antibodies against fungi because fungi contaminate most fermented foods or are contained in them (cheese, kefir, etc).

      Would love to hear more later about what works the best for you!

      • Jason

        Hi Grace,

        Biocidin does have a clay/ charcoal product, but I am hesitant to start that because my issue is SIBO-C/ slow transit. I am currently using their broad spectrum anti-biotic.

        I am taking enteragam for sibo-c. Insurance should cover it. I will find out soon.

        Yes, I understand that fermented foods can cause problems. Sadly that is me. Fermented foods cause me to have sore, irritated eyes and a bit of an immune reaction.

        I would still love to know why you recommend probiotics with sibo while most practitioners do not until later in the healing process. Or perhaps you just recommend soil based organisms over something like VSL#3. I decided to try one packet of VSL# 3 + florastor while weeding with biocidin. I don’t know if this is the right call. Any comments on this topic would be appreciated. Have a good day!

        • DrGracePharmD-Gut_Goddess


          Yes clay/charcoal can hamper motility for some.

          Probiotics are one of the best things to remodel the uppergut. Yes some people worsen because in IBS, IBD and metabolic syndrome (obesity, insulin resistance, T2D, CAD, strokes), high lactobacilli in the uppergut are culprits in causing permeability, fatness, fatigue and fogginess. There is good v bad lacto — generally the good ones don’t release histamine (as your eye reaction can inform, no?)

          Couple of ways to get rid of these — install the good lacto, use high dose bifido or weed (or do all 3). Does that make sense. L casei and bulgaricus are the worse if one is susceptible. L rham and reuteri might be the best. Acidophilus is kinda in between.

          A lot of good probiotics exist — would love to know which work the best for you.

          • Jason

            Thanks Grace. This is a potentially life changing tip! My worst symptom with all this is sleep maintenance insomnia. As you know, life sucks when you can’t sleep well.

            Of all the foods, simple sugars flare my sibo the worst so this may be further evidence that Lacto. is overgrown (or perhaps yeast, but hopefully just lacto). I can get away with eating some starch and bananas/ berries every day. With this in mind, maybe it is time to start some bionic fiber too.

            When I first started taking VSL #3 a year ago, it completely cured me for about 2 weeks. Then I fell into an intermediate state. I wonder if the “bad lacto” in VSL is now overgrown/ dominant, making VSL #3 a double edge sword for me.

            I will try some probiotic tweaking and let you know how things work out. Thank you very much.

          • DrGracePharmD-Gut_Goddess


            I know many practitioners are enthralled with VSL but I think certain probiotics need to be customized for the host/victim lol. There is a ton of strep and lacto in VSL and many gut signatures are already high in these
            –spectrum, ASD
            –metabolic syndrome

            Would love to hear more later — consider fungi still. They are super wily and tenacious for every disease state. They eat all energy sources — including ketones.

        • Libby

          Hi, Jason. Did you see any results with Enteragam? I just started it and also suffer from slow transit. I have Lyme and several co-infections, but also suspect that I suffer from SIBO-C.

          • Jason

            Hi Libby,

            I would say that Enteragam helped me about 10%. What that meant for me is that I slept a little better on it and felt less fatigued. Mode of action? It binds endotoxins and kills some critters. Lyme disease and co-infections….you should check out the work of Stephen Harrod Buhner.

          • Libby

            Thanks, Jason! I have Buhner’s book and there’s A LOT of information in there. I appreciate your feedback.

          • Libby

            Thanks, Jason! I have Buhner’s book and there’s A LOT of information in there. I appreciate your feedback.

          • Jason

            Hi Libby,

            I would say that Enteragam helped me about 10%. What that meant for me is that I slept a little better on it and felt less fatigued. Mode of action? It binds endotoxins and kills some critters. Lyme disease and co-infections….you should check out the work of Stephen Harrod Buhner.

  • Juan Marte

    Hi Dr Grace, i have been following your 7 steps for 2 weeks and feeling better already!. A huge difference for me is the liver support/antioxidants step. i began to feel ill after antibiotics and other meds. I’m taking right now milk thistle and NAC. I want to know how good is turmeric for liver support and how often should i rotate them? 1 month? Thanks for all

    • DrGracePharmD-Gut_Goddess


      AWESOME!! Turmeric is an amazing botanical for every organ system not just the liver and helps to regenerate our naturally produced antioxidants like vitamins and glutathione. Turmeric and other antioxidants like green tea help increase the mucus lining of our gut as well.

      I’m not sure about your question for rotation — the liver/gallbladder/pancreas tends to get hammered by gut dysbiosis because of the crosstalk and blood/lymph circulation that connects the two organs. Consider good liver support/antioxidants until the gut is stable and healed.

      Fatty liver and liver damage are epidemic as a result of a lack of good gut flora in the uppergut (not enough Akkermansia, bifido, soil probiotics and lacto). These all love to consume and live off bionic fiber and our mucus.

  • aquadark

    Hey Dr. G!

    I have a question – since I started the Bionic shakes (acacia + inulin + amazing grass + kefir + rice milk) I’ve gained 10 kilos of almost pure fat over 3 months (which is bad, because at 1.82cm I am almost 105kg), without changing anything else (exercise or diet). Could it be that I’m drinking the shakes first thing in the morning? Maybe they are spiking my insulin/playing with the leptin? I expected the exact opposite effect, because I’ve always struggled with my weight. Because I always give every program or regiment a 3 month trial, I don’t know If I should continue with the shakes or not. Recently, I’m also starting to have pretty darn large stools from them…

    • DrGracePharmD-Gut_Goddess


      Thanks for your comment! Yes leptin/timing could be it… Do you normally drink kefir and/or rice milk? These aren’t a part of bionic fiber.. ahah. Is the kefir dairy or non-dairy? Dairy is excluded initially on the 7 Steps secondary to massive inflammation and trigging gut permeability, until all that is healed up.

      Are you doing probiotics? If you have struggled with fat gat in the past, your gut is likely missing all the major players particularly the ones that keep us thin such as Bifidobacteria longum, certain Lactobacilli and the soil probiotics

      Inulin-FOS does feed certain pathogens and if you do Genova or ubiome, then these can be identified as well as ‘bulking’ up what is missing (Klebsiella and possibly Citrobacter). OTOH Inulin lowers certain pathogens in some studies — Clostridium and E coli.

      Rice milk is a refined high carb food — if you are not generally consuming this regularly then suddenly added in, then I would suspect that the simple carbs are acting like sugar and affecting insulin resistance and the gut flora in an adverse way.