PRIMETIME (AUTOPHAGY)

WHAT MAKES PRIME TIME TO SO IMPACTFUL?

Spermidine
Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan. 

The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms. 

Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways.

Nicotinamide mononucleotide 
Nicotinamide mononucleotide, a naturally occurring molecule present in all species.  NMN is rapidly absorbed and converted to NAD+, which evidence shows declines as we age.  In numerous studies, supplementation has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, and improves neuronal function in the brain among much more.

Epigallocatechin-3-gallate (EGCG) 
Epigallocatechin-3-gallate (EGCG) is the major catechin in green tea.  There is consistency in the literature about the beneficial role of green tea on senescence-related mechanisms, thanks to its scavenging properties against reactive oxygen species (ROS) and reactive nitrogen species (RNS) and its ability to stimulate autophagy 

Alpha-ketoglutarate (AKG)
Alpha-ketoglutarate (AKG) is a molecule involved in several metabolic and cellular pathways that declines with age. It works as an energy donor, a precursor in amino acid production, and a cellular signaling molecule, and it is a regulator of epigenetic processes. 

Dihydroquercetin (Taxifolin) 
Dihydroquercetin is a powerful antioxidant of plant origin that can protect cells from the harmful effects of free radicals and protect cell membranes against damage

Apigenin
Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties.  It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels.

Luteolin
Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress.  

Trimethylglycine (TMG)
Trimethylglycine (TMG) is an amino acid derivative that occurs in plants and has been shown to support methylation which, in turn, supports the homocysteine levels. Taking TMG along with NMN provides the ideal balance for NAD+ production in the body. 

Resveratrol 
Resveratrol is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.The anti-aging mechanisms of resveratrol are mainly modulating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol is considered for the prevention and support of aging and age-related diseases as it mimics the effects of calorie restriction. 

Pterostilbene
Pterostilbene is a phenolic compound in the same family as resveratrol and is present in small amounts in a large variety of foods and beverages like blueberries or red wine. Multiple studies confirm pterostilbene's remarkable anti-aging effects. Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and sirtuins

Bergamot
Bergamot (Citrus bergamia) is a type of citrus fruit native to Italy. It has been shown that bergamot juice exerts antioxidant, cardioprotective properties and antisenescence effects. 

AstraGin® 
AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous. AstraGin® increases the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating absorption-specific m RNA and transporters such as SGLT1, CAT1, and GLUT4.